Pamela Adlon (nee Segall; born July 9, 1966) is an American actress, voice actress, screenwriter, producer, director, and creator.

She voiced Bobby Hill on the animated comedy series King of the Hill (1997-2010), for which she won a Primetime Emmy Award, Ashley Spinelli on the animated comedy series Recess (1997-2003), and the title character from the Pajama Sam video game series. Her other voice work for cartoon series includes Bobby's World, Quack Pack, Jumanji (1996), Jungle Cubs, Recess, 101 Dalmatians: The Series, The Oblongs, Kid vs. Kat, Squirrel Boy, Pound Puppies, Bob's Burgers, Thundercats (2011), Rick and Morty, Big Mouth, and Human Resources. She provided the voice of Vidia in several Tinker Bell movies. She has also voiced for other animated movies including FernGully: The Last Rainforest, The Trumpet of the Swan and The Animatrix, as well as the movies from the TV cartoon series Recess.

Notably, she provided the voice of Mrs. Wolowitz, Howard's mom, on The Big Bang Theory.

She is known for her roles on the comedy-drama series Californication (2007-2014) and Louie (2010-2015), on which she was also a writer and producer. Since 2016, she has starred as Sam Fox on the FX comedy-drama series Better Things, which she also co-created, writes, produces and directs.

Her movies include Say Anything..., The Adventures of Ford Fairlane, Bed of Roses, Sgt. Bilko, Bumblebee, and The King of Staten Island.